Carbonic anhydrase as biomarker for cancer diagnosis

Carbonic Anhydrase (CA) is an enzyme that is integrated into the cell membrane that stimulates the reversible hydration of CO2 producing bicarbonate and hydrogen ions, and its study has gained relevance in the last years because it is related to several types of cancer such as; lung, kidney, colon, uterus, and stomach cancer (4, 5, 6,7,8). Therefore, different studies report carbonic anhydrase as an excellent biomarker for the early detection of lung cancer. Over the last few years, it is being used as a biomarker for the detection of lung cancer, as mentioned by Lin et al. (48), in their work, where they report a direct relationship between the overexpression of carbonic anhydrase and lung cancer. The present study assesses different methods where techniques are used to evaluate it by means of an electrochemical biosensor. These techniques will enable us to continue with the analysis of the characteristics that allow the recognition of carbon anhydrase in a range of 1.08-1.32mM with an acceptable sensitivity with a response time of 1s, demonstrating a promising technology for the application of lung cancer detection.